Magnesium ascorbyl phosphate (also called magnesium ascorbityl phosphate or magnesium L-ascorbyl-2-phosphate) has a chemical formula of C. In another embodiment, sodium metabisulfite and magnesium ascorbyl phosphate are used in about 0.01% (preferably from about 0.05% to about 0.5%, most preferably at least about 0.1%,) and about 0.5% (preferably from about 0.25% to about 3%, more preferably from about 0.25% to about 1%, and most preferably at least about 0.5%) respectively in a composition with about 4% hydroquinone. I'm using it for spot treatment of some hyper pigmentation (less than 1% of my body). Diamines, useful in the rubber industry as antiozone agents, are similarly produced from aniline: Hydroquinone has a variety of uses principally associated with its action as a reducing agent that is soluble in water. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. 109. All Rights Reserved, View All Eastman Hydroquinone USP Articles. The obtained results show that the solubility of benzoic acid in water is greater than that of salicylic acid, but in the case of the two isomers of dihydroxybenzene, the solubility of resorcinol is approximately 100 times that of hydroquinone. The natural pH for conventional hydroquinone compositions is acidic, generally less than about 4 even though this is harsh to the skin and to other components of the product. https://doi.org/10.1007/s10765-020-02750-4, DOI: https://doi.org/10.1007/s10765-020-02750-4. Thus, while cationic salts of acidic ascorbyl esters, preferably magnesium ascorbyl phosphate and aminopropyl ascorbyl phosphate, have beneficial antioxidant effects on the skin, the combination with hydroquinone in the invention results in a compatible and stable composition. wG xR^[ochg`>b$*~ :Eb~,m,-,Y*6X[F=3Y~d tizf6~`{v.Ng#{}}jc1X6fm;'_9 r:8q:O:8uJqnv=MmR 4 GHS H Statement: Causes serious eye damage.Suspected of causing genetic defects.May cause an allergic skin reaction.Suspected of causing cancer.Harmful if swallowed.Very toxic to aquatic life. In the environment, hydroquinone showed increased toxicity for aquatic organisms, being less harmful for bacteria and fungi. Dietland Muller-Schwarze, 2003, page 43 (, National Institute for Occupational Safety and Health, Additive manufacturing of ceramics from preceramic polymers, http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=CELEX:31976L0768:EN:HTML, "Clear N Smooth Skin Toning Cream recalled", Skin Bleaching Drug Products for Over-the-Counter Product Use; Proposed Rule, "About the Center for Drug Evaluation and Research - Hydroquinone Studies Under The National Toxicology Program (NTP)", Campaign For Safe Cosmetics - Hydroquinone, "Skin lightening preparations and the hydroquinone controversy", https://en.wikipedia.org/w/index.php?title=Hydroquinone&oldid=1136453324, Wikipedia articles needing page number citations from October 2016, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License 3.0, The most widely used route is similar to the, A potentially significant synthesis of hydroquinone from, Hydroquinone was first obtained in 1820 by the French chemists, Pelletier and Caventou (1820) "Recherches chimiques sur les quinquinas" (Chemical investigations of quinquinas [i.e., the bark of various, This page was last edited on 30 January 2023, at 11:09. The information given is designed only as a guide for safe handling and use. [21][25][23] NTP evaluation showed some evidence of long-term carcinogenic and genotoxic effects[26], While hydroquinone remains widely prescribed for treatment of hyperpigmentation, questions raised about its safety profile by regulatory agencies in the EU, Japan, and USA encourage the search for other agents with comparable efficacy. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), which are protected have been shown to also be color stable in hydroquinone, magnesium ascorbyl phosphate and sodium metabisulfite composition at about a neutral pH, preferably from about 5.5 to about 8.0, more preferably from about 5.5 to about 7.5, and most preferably from about 6.0 to about 7.5. Found. S.C. Gad, T. Pham, in Encyclopedia of Toxicology (Third Edition), 2014 Environmental Fate and Behavior. I can't use water because I cannot dissolve enough Hydroquinone into it to reach the desired concentration. V)gB0iW8#8w8_QQj@&A)/g>'K t;\ $FZUn(4T%)0C&Zi8bxEB;PAom?W= However, the oil-soluble TBHQ is more hydrophobic with a distinctly increased log P value compared to HQ. These reactions release free oxygen and generate enough heat to bring the mixture to the boiling point and vaporize about a fifth of it, producing a hot spray from the beetle's abdomen. Remove contact lenses, if present and easy to do. Forms of retinoids have been developed wherein the retinoid is protected by a protective system. HYdroquinone can be found in various skin care products. Natural antioxidants could replace hydroquinone derivatives used in industry. The solubility in water is 6.72g/L. In 1-octanol, the decreasing order of the solubility of these compounds is as follows: resorcinol>benzoic acid>salicylic acid>hydroquinone. Thermodyn. ChemPoint will not under any circumstances release personal user information to individuals or companies. STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN. endstream endobj 1 0 obj <> endobj 2 0 obj <> endobj 12 0 obj <>stream [22] The FDA stated that hydroquinone cannot be ruled out as a potential carcinogen. %PDF-1.4 % It can also be found on eBay and Amazon. A common route involves hydroxylation of phenol. Some may double boil the hydroquinone and ester, I was too scared of the possibility of combustion. Formula of hydroquinone is . 76/768/EEC:1976 Council Directive 76/768/EEC of 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products: Organic Chemistry, Solomon and Fryhle, 10th edition, Wiley Publishing, 2010. However, hydroquinone discolors at the pH range of 7.0 to 8.5. Hydroquinone | C6H4(OH)2 or C6H6O2 | CID 785 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities . This website uses cookies. Thank you for your inquiry and interest in ChemPoint. fungichromin, Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. Conversion factors (at 25C and normal atmospheric pressure) 1 ppm = 4.5 mg/m 3 1 mg/m 3 = 0.222 ppm Table 1. These phases (described below) are combined in a mixing tank with an in-line homogenizer as follows. sulfur acids, imidic, hydrazonic, hydroximic acids, Carboxylic acids, e.g. Glycerol derivatives solubilise natural, hydrophilic antioxidants in biofuels. protecting the retinoids in a protective system; mixing the hydroquinone, and the protected retinoids; and. 0.6. glycerin, 2.5. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Availability. The preferred form of protected retinol is manufactured by SunSmart (also known as Particle Sciences, Inc. of Bethlehem, PA) under the brand name of SunCaps A-1283. Toxicol. Have an order or account question, find answers in our Online Support articles. 114, 175188 (1996), I. Hahnenkamp, G. Graubner, J. Gmehling, Int. 0000002585 00000 n So, does anybody know of another solvent I could use that has a higher . If youre making your lotion. Eastman Hydroquinone, USP, meets or exceeds the requirements of the United States Pharmacopoeia and is produced under conditions of current good manufacturing practices (cGMP). I made my own hydroquinone 4% and added it to my cream. Some documentation and label information may refer to the legacy brand. 0000085850 00000 n 250, 165172 (2006), F. L. Mota, A. J. Queimada, A. E. Andreatta, S. P. Pinho, E. A. Macedo, Fluid Phase Equilib. Cite this article. Table II shows that at 5C, 4% hydroquinone compositions maintain their white or light straw color with the addition of at least about 0.5% magnesium ascorbyl phosphate at the low pH ranges (from about 3.50 to about 5.50) and when about 1.0 to about 2.0% magnesium ascorbyl phosphate is used in the pH range of about 7.0. : Metabolism and disposition of hydroquinone in Fischer 344 rats after oral or dermal administration. Stir until uniform. application/pdf You can expect to hear from a technical specialist within 1 business hour. and solubility in water. Hydroquinone is a white, odorless, crystalline solid with an extremely low vapor pressure. These can be burning, redness, sensitization and irritation in some patients. The Boiling Point of hydroquinone is 287C Also, the Melting Point of hydroquinone is 172C. Find answers in our support articles. 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